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Senior Scientist II, Computational Biology

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Worcester, Worcester
Posted 13 hours ago
11 views

Job Description

AbbVie is seeking an innovative and technically proficient scientist to lead the integration of statistical and computational methodologies into analysis workflows for Complex In Vitro Models (CIVM), including organoids, organ-on-a-chip, and advanced multicellular systems. This role will champion multi-modal phenotyping, manage centralized metadata, and drive the development of robust pipelines for hypothesis testing, causal inference, and predictive modeling using multi-omics datasets. The ideal candidate will be instrumental in standardizing and harmonizing data formats and workflows across Immunology sites, collaborating with researchers to build scalable, reproducible data pipelines.

Key Responsibilities:

  • Integrate statistical analysis and computational techniques into multimodal data workflows (imaging, spatial omics, etc.) to extract actionable biological insights.
  • Collaborate with discovery scientists to design and analyze experiments, translating human-derived hypotheses into mechanistic wet lab assays.
  • Lead development of scalable, reproducible pipelines for hypothesis testing, causal inference, and predictive modeling across imaging and multi-omics datasets.
  • Guide statistical planning for in vitro (and in vivo studies as needed), including power/sample size calculations, randomization, and reproducibility standards.
  • Ensure statistical rigor and appropriate evaluation strategies in interpreting experimental results, supporting go/no-go decisions and milestone reviews, especially for data from in vitro assays.
  • Work closely with translational scientists, imaging scientists, bioinformaticians, and pathologists to translate scientific questions into computational solutions.
  • Balance innovation with practicality, ensuring solutions are scalable, interpretable, and fit-for-purpose.
  • Mentor junior scientists and foster a collaborative, innovative research environment.
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