The Discovery Rheumatology group within AbbVie is responsible for identifying and validating novel therapeutic targets for the treatment of many rheumatic diseases. We have an exciting opportunity available for an Associate Scientist to join our team at our Cambridge site near Boston, MA. The successful candidate will be responsible for developing and executing a broad range of in vitro cell-based and molecular experiments, including cell culture, plate-based assays, and cellular/molecular profiling using the latest instrumentation from real-time cell imaging to highly sensitive multiplex protein characterization. This role requires the analysis, interpretation, communication, and presentation of high-quality, reproducible data sets to support multiple programs across the rheumatology portfolio. This is a lab-based position and requires full-time on-site presence. Successful candidates will thrive in a collaborative lab environment.

Key responsibilities include: 

• Optimize & support cell-based functional studies: work within the target identification & validation team to develop and execute on multiple functional studies with primary human cells using real-time cell imaging and flow cytometric profiling to track cell growth, survival and migration. Broaden skills to enable effective planning and execution of high throughput screens and gain experience with the latest technologies in cell-based profiling.
• Perform analytical assays & support troubleshooting: conduct analytical assays to evaluate both RNA and protein composition from in vitro cell cultures and patient-derived biospecimens by qPCR and ELISA-type technologies, respectively. Generate high-quality data to support selection of disease relevant cell culture and stimulation conditions to drive target candidate nominations. Develop the skills to independently troubleshoot assays and instruments to ensure consistent quality data output.
• Analyze & communicate results: analyze study results, organize and document the results in an electronic lab notebook (ELN), and effectively communicate updates, troubleshooting, and results to the team. Interpret results and draw conclusions from multistage experiments with support from study owners and project leads. Communicate aberrant data and lab issues to management to gain input and alignment on solution.
• Collaboration: Collaborate closely with highly matrixed team members to support pipeline programs and participate in project teams as a study owner