The Biologics CMC Development team at AbbVie in the Bay Area has a long and rich history of biologics development.   Located in a new state of the art facility in South San Francisco, the team leverages its comprehensive end-to-end CMC capabilities to work collaboratively through all phases of CMC development with a primary focus on advancing complex biologic therapies, such as bi-specifics and novel modalities, to human clinical studies and eventual licensure. 

The Cell Line Development Group in South San Francisco, CA is seeking an Associate Scientist II to join a talented and collaborative team developing CHO cell lines for GMP applications. In this laboratory position the candidate will perform hands-on CHO cell line development for pipeline assets and support the establishment of automation capabilities in the group to increase throughput. The successful candidate will contribute to the evaluation and implementation of an automated liquid handler for cell culture workflows.

Key Responsibilities:

• Perform CHO cell line development, including transfection, selection, single cell subcloning, growth and productivity screening, cell banking and stability assessment of cell banks.
• Support the evaluation and implementation of liquid handlers like Tecan, Biomek or Hamilton for cell culture workflows.
• Culture mammalian cells across multiple scales and formats, from 96-well plates up to shake flasks.
• Operate instruments like ViCell automated cell counter, Octet, Clone Select Imager, microscope, HPLC, Ambr®15, Beacon, SONY flow cytometer and liquid handlers (Tecan, Biomek and Hamilton). Share responsibility for equipment maintenance.
• Co-author cell line development technical reports that meet expectations of regulatory agencies for all stages from IND to BLA. 
•  Collaborate closely with cell culture, purification, analytical and formulation development colleagues to meet project timelines.
• Actively support opportunities to execute improvements to the cell line development workflow, including automation, assessment of new technologies and equipment. 
• May generate data for internal or external conferences or consortia. 
• Display effective organization, verbal and written communication skills, and adherence to good documentation practices.