Janux Therapeutics is seeking a hands-on, execution-driven Clinical Pharmacology Lead to support the design, analysis, and interpretation of clinical pharmacology strategies across our development programs. This role is ideal for a scientific contributor who thrives on working directly with data, ensuring high-quality PK analysis, and enabling data-informed decisions for dose selection and regulatory filings.
This position is focused on executional excellence, not modeling ownership. PK/PD modeling and simulation may be supported externally, while this role ensures internal strategic alignment and scientific rigor in clinical pharmacology deliverables.
ESSENTIAL FUNCTIONS AND RESPONSIBILITIESServe as the Clinical Pharmacology Lead across multiple programs, owning the execution of clinical pharmacology plans from IND through early clinical development.Design and oversee PK, PK/PD, and exposure-response analyses to support dose selection, study design, and benefit-risk assessments.Lead the development and execution of clinical pharmacology components of studies, including food effect, drug-drug interaction, organ impairment, and QT assessments.Author and review clinical pharmacology sections of regulatory documents (e.g., INDs, NDAs, briefing books) and support regulatory interactions.Ensure proper bioanalytical sampling strategies, assay validation, and data quality across studies.Collaborate with Translational Medicine and Biomarker teams to integrate mechanistic and biomarker data into PK/PD interpretation.Work closely with Biometrics and external modeling partners to support population PK and exposure-response modeling.Stay current with regulatory guidance and scientific advances in clinical pharmacology, applying best practices to development programs.Contribute to program-level planning and prioritization based on pharmacological insights and development risk.Other activities as required.REQUIRED EDUCATION, EXPERIENCE, SKILLS, AND ABILITIESPh.D., Pharm.D., or equivalent in Clinical Pharmacology, Pharmaceutical Sciences, or a related field.6+ years of experience in clinical pharmacology and/or pharmacometrics in the biotech or pharmaceutical industry.Direct experience designing and executing early-phase clinical studies, including healthy volunteer studies.Strong expertise in PK analysis and exposure-response interpretation; experience in oncology or biologics preferred.Familiarity with T cell engagers (TCE) and managing external Clinical Pharmacology resources.Proven track record of contributing to regulatory submissions and engaging with health authorities.Excellent communication, collaboration, and organizational skills.Ability to work independently and in a fast-paced, matrixed environment.Ability to travel up to 15%Job Type: Full-time
Benefits:
· 401K
· Medical insurance
· Dental insurance
· Vision insurance
· Supplemental disability insurance plans
· Flexible schedule
· Life insurance
· Flexible vacation
· Sick time
· Incentive stock option plan
· Relocation assistance
Schedule:
· Monday to Friday
Work authorization:
· United States (Required)
Additional Compensation:
· Annual targeted bonus %
Work Location:
· On site (San Diego, CA)
EQUAL OPPORTUNITY EMPLOYER:
Janux Therapeutics, Inc. is an equal opportunity employer that is committed to providing a work environment free of harassment and discrimination based upon a protected category, as well as an environment free from retaliation for protected activity.
Notice to Recruiters and Third-Party Agencies
The Talent Acquisition team manages the recruitment and employment process for Janux. To protect the interests of all parties involved, Janux will only accept resumes from a recruiter once a fully-executed search agreement is in place. Agencies are hereby specifically directed not to contact Janux employees directly in an attempt to present candidates. Janux will consider any candidate for whom an Agency and/or Recruiter has submitted an unsolicited resume to have been referred, free of any charges or fees.
