Summary:

Vaxcyte is seeking a Director, Health Economics & Outcomes Research (HEOR) to establish and lead the company’s health economic strategy across the vaccine lifecycle, with initial focus on adult pneumococcal programs. This strategic leadership role will be responsible for developing and executing global health economic models to support payer value propositions, immunization policy engagement, reimbursement strategy, and external stakeholder communications.

This role will focus specifically on health economic modeling and payer value strategy. Observational real-world evidence and epidemiology studies will be led by the Epidemiology & Real-World Evidence function. The Director, HEOR will work in close collaboration with RWE and Epidemiology colleagues to ensure economic models are grounded in robust disease burden, vaccine effectiveness, and coverage assumptions.

As Vaxcyte advances toward commercialization, this role will partner closely with Market Access colleagues, who will lead pricing and contracting strategy. The Director, HEOR will provide the analytic foundation and economic evidence required to inform pricing strategy, payer engagement, and health technology assessment discussions.

Essential Functions:

Health Economic Strategy & Leadership

• Develop and lead Vaxcyte’s HEOR strategy across early development, launch planning, and lifecycle management.
• Define the economic evidence generation plan required to support payer access and policy recommendations.
• Ensure health economic considerations are incorporated early into development planning.

Health Economic Modeling

• Lead development of cost-effectiveness, budget impact, and population health models for adult and pediatric vaccine programs.
• Design and oversee decision-analytic models (e.g., Markov models, microsimulation models, dynamic transmission models as appropriate).
• Establish modeling assumptions grounded in epidemiologic, clinical, and real-world data.
• Ensure all models are scientifically rigorous, transparent, and defensible in policy and payer environments.

Value Communication & Policy Support

• Translate health economic findings into clear, compelling value narratives for internal leadership and external stakeholders.
• Support development of global value dossiers, AMCP dossiers, and materials for payer engagement.
• Contribute to peer-reviewed publications and scientific congress presentations.

Cross-Functional Partnership

• Partner closely with Epidemiology & RWE to integrate disease burden and vaccine effectiveness assumptions into economic models.
• Collaborate with Clinical Development, Regulatory, Medical Affairs, and Market Access teams to align value strategy.
• Support consistent, aligned value messaging across stakeholders.

Capability Building

• Establish best practices and governance processes for health economic modeling.
• Build and manage external modeling partnerships.
• Mentor future HEOR team members as the function expands.

Requirements: 

PhD in Health Economics, Health Services Research, Public Health, Epidemiology, or related quantitative field with 8+ years of relevant industry experience required OR Master’s degree (e.g., MPH, MSc, MBA) with 12+ years of relevant industry experience in health economic modeling.

• Demonstrated experience leading cost-effectiveness and budget impact models.
• Deep expertise in decision-analytic modeling methodologies.
• Experience supporting payer submissions or health technology assessments.
• Strong cross-functional leadership and communication skills.