Position description:

Calico is seeking an intern to join the Parkinson’s Disease Initiative. To succeed, you will need to be an enthusiastic team player, detail-oriented, extremely organized and comfortable working on complex problems.  In this position you will develop a novel imaging-based experimental system to study 𝝰-synuclein dynamics in vitro and in living cells, focusing on its oligomerization and aggregation regulated by disease-relevant perturbation. The successful candidate will work closely with members of the Parkinson’s Disease Initiative and the imaging team to develop a labeling strategy for 𝝰-synuclein using codon expansion technology. 

Responsibilities: 

• Optimize a genetic code expansion approach to site-specifically label alpha synuclein with fluorophores
• Proof-of-concept implementation of the labeling system in cell culture
• Perform biophysical characterization of labeled synuclein using rotational diffusion methods fluorescence polarization and tumbling methods in vitro and in living cells
• Explore experimental perturbations to induce changes in synuclein trafficking, oligomerization, aggregation and clearance

Position requirements:

• Currently pursuing a PhD degree, in biophysics, cell biology, neuroscience or a related field 
• Experience working with fluorescence microscopy, flow cytometry
• Knowledge of physical modeling of biological processes, quantitative imaging analysis
• Familiarity with standard molecular biology and tissue culture methods
• Detail-oriented and organized
• Strong teamwork and communication skills
• Self-motivated with a “can-do” attitude
• Flexible, able to respond quickly to shifting priorities and able to multitask

Nice to have:

• Experience in genetic screening, codon expansion system, Parkinson’s disease

About our Program:

Calico’s internship program is a paid 12-week program over the summer for students interested in understanding the fundamental science of aging and finding treatments for the associated and intractable diseases. Working in a collaborative environment and fully embedded in one of our labs/teams, Calico interns tackle a unique project under the mentorship of at least one of our scientists or engineers. 

Program Features:

• 3-month summer timeline
• In-person experience at our offices in South San Francisco
• Matching with at least one Calico mentor
• Group supplemental activities weekly featuring guest speakers, Senior Leadership spotlights, and discussion groups on aging science, our drug development approach, and more
• End-of-summer company-wide project showcase and poster session
• Competitive compensation ($45 - $70/hour) and monthly living expenses stipend
  

Program Eligibility:

• Able to work in-person at our offices in South San Francisco
• Free for a consecutive period of 11-12 weeks in June, July, and August
• Not graduating before December 2026
  • Exception for students enrolling into a graduate degree program in Fall 2026
• Must be enrolled in a US university
• Must apply by application deadline: February 1, 2026.