The Biologics CMC Development team at AbbVie in the Bay Area has a long and rich history of biologics development. Now located in a new state of the art facility in South San Francisco, the team leverages its comprehensive end-to-end CMC capabilities to work collaboratively through all phases of CMC development with a primary focus on advancing complex biologic therapies, such as bi-specifics and novel modalities, to human clinical studies and eventual licensure.

AbbVie’s Biologics CMC Analytical Research and Development Group in South San Francisco has an exciting opportunity for a Principal Research Scientist 1 to join a new team responsible for process analytics. The Process Analytics team’s mission is to provide enhanced understanding of cell line, upstream, and downstream processes, and to streamline process development decisions and timelines through application of data-rich, high-throughput, rapid-turnaround analytics, and automation. 

In this role, you will report to the Process Analytics team lead and be responsible for analytical testing and evaluation of process intermediates to enable cell line, cell culture, and purification development. Additionally, you will be responsible for conceiving, developing, and implementing innovative, fit-for-purpose in-process methods that advance analytical capabilities to enable cell line and process development.

Responsibilities include:

• Conceive and develop innovative, data-rich, high-throughput, and automated in-process analytical methods and workflows to enable and enhance process understanding and process development efficiency.
• Perform analytical testing of process intermediates using diverse methods.
• Collaborate closely with Cell Line Development and Process Development scientists to plan and execute analytical testing for process development experiments.
• Interpret and communicate in-process analytical results to cross-functional collaborators and stakeholders in a manner that informs cell line selection and process development decisions.
• Collaborate and communicate effectively with Analytical Molecule Leads to provide data and results from in-process testing for consideration in the context of the overall Analytical Development/QC control strategy.
• Engage with analytical subject matter experts (SME) to investigate in-process findings that warrant further interrogation with advanced extended characterization methodologies.
• Work efficiently, collaboratively, and cross-functionally toward project timelines and goals.
• Serve as an SME for in-process analytics on cross-functional teams.
• Document laboratory work according to good documentation practices.
• Supervise 0-2 direct reports.
• This position is an onsite, lab-based role.
• To be successful, candidates must enjoy and thrive in a highly collaborative lab environment with daily face-to-face cross-functional interactions between scientists.