AbbVie Process Chemistry is responsible for the chemical development of AbbVie’s clinical candidates. We are seeking a Principal Research Scientist I/II to conduct process research and development of drug conjugates from pre-clinical through clinical development.

We are looking for a highly motivated person who can make scientific contributions across synthetic molecule modalities, with a focus on driving the development of drug-conjugate programs from FIH to late-stage development. The candidate will lead in the development of conjugation chemistry as well as downstream unit operations culminating in drug substance and may have supervisory responsibilities. The candidate will serve as the chemistry representative on the CMC team for drug-conjugate development programs and would be responsible for developing timelines and executing activities required for drug substance. The candidate must be able to mentor and develop staff with novel experimental approaches to answer difficult scientific questions. Working with analytical and manufacturing colleagues, the candidate will develop productive collaborations and communications with scientific teams.

Responsibilities:

• The candidate will lead activities associated with process development and characterization for new drug conjugates.
  • Develop and characterize drug-conjugate (and other modalities) processes in the laboratory and translate them to scalable processes.
  • Proactively advise and share knowledge and expert opinions with subordinates, peers, and senior management. Mentor staff in troubleshooting strategic and experimental issues.
  • Author and review key regulatory documents, laboratory data, technical memos and reports.
• The position involves multi-disciplinary interactions with organic chemists, analytical chemists, engineers, drug product development, and program management.  The selected candidate will collaborate with cross-functional CMC teams to advance pre-clinical and clinical candidates.
• The candidate will encourage ideas for continuous improvement activities and initiatives within work group.
• The candidate will understand and adhere to corporate standards regarding code of conduct, safety and GXP compliance.