The Opportunity
We seek a Principal Scientist II, Analytical Development to join an experienced, fast-paced and collaborative team. This position will be primarily responsible for guiding the biophysical analytical strategy and developing novel analytical methods for characterizing AbbVie’s mRNA-based targeted lipid nanoparticles (tLNPs) pipeline. This role will manage a small team of scientists focused on biophysical methods for characterizing intact tLNPs and the targeting ligands. Working closely with the technology development and research teams, this position will guide development of novel characterization methods, drive process/product understanding, support expansion of the tLNP platform and pipeline, and support product investigations.

Responsibilities & Duties:

• Lead strategy for and development of novel biophysical methods to characterize tLNP drug product and protein components, including but not limited to LC/CE/MS, DLS, MALLS, Nano flow cytometry, mass photometry, BLI, and plate-based assays
• Design and lead structure-activity relationship and extended characterization studies to improve tLNP function and stability
• Support product characterization for tLNP platform/formulation development and lead candidate selection
• Establish automation/lipid chromohigh throughput (HTP) workflows and in-process analytical methods for routine and non-routine testing of the tLNP pipeline
• Represent functional area in cross-functional pipeline and technology development teams. Effectively communicate complex technical topics to collaborators and management
• Support method transfer and qualifications as needed
• Manage and develop a team of 2-5 scientists
• Draft technical reports and documents as needed