Location: Newton, MA (on-site)

Position Summary:

In this role you will be responsible for the design and day-to-day operation antibody and protein purification, characterization and protein analytics workflows at Invivyd. This position will work collaboratively with antibody discovery researchers and project managers. As part of a small research team, you will report to a PhD scientist and have the opportunity for scientific and professional mentorship and well as ownership of your research work. You will play a key technical role in the experimentation required to discover and advance candidate antibody molecules for development. The successful candidate will serve as a key member of the R&D team, supporting the up/down selection of antibody candidates throughout the therapeutic discovery and development process.

Responsibilities:

• Contribute to Invivyd’s protein production and analytics workflow
• Demonstrates reliable technical skills in a focused number of methodological areas including various binding and biophysical characterization techniques including biosensor (Octet, Biacore) assays, thermal stability, and light scattering
• Purify proteins and antibodies using FPLC systems (Akta) and various from of chromatography
• Assist in developing new assays for protein characterization within the context of antibody discovery campaigns
• Support basic Antibody engineering efforts, including Fab and scFv preparation and purification
• Ensure effective, high-quality, timely and appropriate documentation in electronic laboratory notebooks
• Performs initial analysis of experimental data and interprets immediate experimental outcomes and/or conclusions within established protocols
• Participates in the planning and performance of experiments within standard procedures with minimal supervision
• Troubleshoots routine technical problems within standard procedures and performs regular quality control audits on instrumentation and associated outputs
• May be expected to present during internal research and development team meetings

Requirements: Questions to consider below.

• Bachelor’s degree in molecular biology, biochemistry, or a related field, and 1+ years of bench Industry experience
• Experience in mammalian and bacterial cell culture with an emphasis on protein expression
• Strong knowledge and wet-lab experience performing protein purification and characterization using Akta FPLC systems, BLI (highly preferred), and functional assays
• Experience or understanding of various analytical methods for protein characterization and developability assessment of drug candidates is preferred
• Proactive team player and flexibility to work on multiple projects as the discovery programs evolve over time
• Ability to design and execute antibody discovery workflows and interpret in-process readouts
• Excellent verbal and written technical and non-technical communication skills