The Biologics CMC Development team at AbbVie has a long and rich history of biologics development. Now located in a new state of the art facility in South San Francisco, the team leverages its comprehensive end-to-end CMC capabilities to work collaboratively through all phases of CMC development with a primary focus on advancing biologic therapies, such as monoclonal antibodies, bi-specifics and novel modalities, to human clinical studies and eventual licensure. This role will be imbedded in a team of highly experienced scientists and managers who have directly enabled the development/IND submissions of 20+ novel oncology drugs and successfully filed two BLAs.

The Cell Culture Development Group in South San Francisco, CA is seeking a Senior Scientist I to join a talented and collaborative team to develop and implement machine learning models for predicting optimal cell culture process performance. As a senior scientist, you will be responsible for all aspects of ML model development.

This position is an onsite role in a lab-based function. To be successful, candidates must enjoy and thrive in an onsite, highly collaborative lab environment with face-to-face cross-functional interactions between scientists.

In this position, you will perform cell culture process modeling, cell culture process development, scale-up, and technology transfer activities in a well-supported and dynamic environment to help advance novel biotherapeutics into human clinical studies. 

KEY RESPONSIBILITIES:

• Develop, implement, refine, and validate machine learning (ML) models for predicting cell culture process performance
• Communicate model findings and suggest experimental strategy and/or workflow improvements to support early- and late-stage development
• Actively seek out opportunities to optimize our platform or enhance our understanding of cell culture processes using ML models and wet lab experiments
• Design and execute scalable ambr250, 2L, 50L, 200L and 500L single use bioreactors processes
• Represent the cell culture development group in cross-functional meetings and collaborate closely with cell line, purification, analytical and formulation development leads to meet project deliverables and timelines
• Publish or present scientific findings in peer-reviewed journals, internal or external conferences or consortia  
• Display effective organization, verbal written communication skills, and adherence to good documentation practices