The Biologics CMC Development team at AbbVie has a distinguished history of advancing complex biologic therapies through all phases of development, from discovery to licensure. Our state-of-the-art facility in South San Francisco provides comprehensive CMC capabilities and a highly collaborative environment focused on innovative drug substance development. You will join a team that has enabled 20+ IND submissions and two successful BLAs.

We are seeking a highly motivated Senior Scientist I to join the Purification Development team. This individual will apply mechanistic modeling  and/or advanced AI / machine learning (ML) strategies to the development, optimization, and scale-up of robust, phase-appropriate purification processes for biotherapeutic candidates. The ideal candidate will leverage historical and incoming process data to drive process understanding, forecast outcomes, and accelerate project timelines.

Key Responsibilities:

• Design, implement, and validate mechanistic models and/or AI/ML (e.g., for process performance prediction, process understanding, and workflow optimization) using historical and real-time data from lab scale purification development and pilot/GMP manufacturing.
• Actively seek out opportunities to optimize current platform or enhance our understanding of purification unit operations using advanced models and wet lab experiments.
• Contribute to or drive mechanistic modeling efforts for chromatography and/or membrane separations, supporting process control and troubleshooting.
• Execute wet lab validation experiments with detailed documentation practices.
• Collaborate closely with cross-functional teams to meet project deliverables and timelines.
• Analyze complex datasets, utilize advanced data visualization tools, and communicate data-driven recommendations to technical teams.
• Proactively monitor relevant scientific literature and integrate innovative bioprocess advances.
• Write technical publications, reports, presentations, and regulatory filings; publish research in peer-reviewed journals and present work at scientific conferences.
• Mentor junior staff and uphold best practices in documentation, safety, and GxP compliance where applicable.