AbbVie is looking for a Senior Scientist to join our Genetic Medicine in vivo CAR-T group within the Biotherapeutics and Genetic Medicine (BGM) department. This role will involve designing and executing innovative experimental approaches to address key scientific challenges related to in vivo lentiviral delivery platforms. The successful candidate will drive scientific innovation, identify and implement new methods and techniques, and collaborate cross-functionally to advance our pipeline of novel in vivo CAR-T therapies.
Responsibilities:
- Lead research efforts, design and execute in vitro studies (multi-color flow cytometry, ELISA, luciferase, ddPCR, etc.) and collaborate with in vivo pharmacology group for in vivo studies to advance lentiviral-based delivery platform development.
- Design and engineer lentiviral vectors and fusion protein receptors, and oversee lentiviral production by leveraging internal capabilities and external CRO partnerships.
- Partner with cross-functional and therapeutic area teams to advance lentiviral-based in vivo CAR-T pipeline programs from early discovery through translational development.
- Uphold company culture, teamwork, and safety standards, including appropriate handling of materials in a BSL-2 environment.
- Work independently with minimal supervision while maintaining a high level of productivity, efficiency, and scientific rigor.
- Maintain comprehensive and well-documented records in an Electronic Lab Notebook (ELN).
- Analyze and interpret multidisciplinary data to generate actionable conclusions, identify key risks, and guide future experimental directions.
- Collaborate and effectively communicate results with key stakeholders and cross-functional teams throughout the organization.
- Contribute as a primary author to scientific publications, presentations, and/or as a primary inventor of patent applications.
- Demonstrate a proactive, solutions-oriented mindset and take ownership of additional responsibilities as needed.
- Mentor and support junior scientists within the team.
