The Quantitative, Translational and ADME Sciences (QTAS) group is searching for a Senior Scientist to provide mechanistic and translational modeling and project support in all disease areas, informing decision-making for primarily large, but also small molecule projects from discovery through the early stages of clinical development. The candidate will establish innovative translational modeling approaches, such as mechanistic PK/PD or systems modeling, across disease and therapeutic areas, as well as provide QTAS project support enabling translation of assets from Discovery into early Development. The position requires close collaboration with Discovery and Development project teams, clinical pharmacology, and other stakeholders, to develop and execute QTAS and PK/PD strategies necessary to facilitate the advancement of our pipeline. 

Key Responsibilities: 

• Develop and implement innovative, quantitative analyses and strategies for translational modeling across Discovery and Development projects 

• Liaise with Discovery biology, pharmacology, toxicology, biomarker, QTAS and clinical scientists to generate data and knowledge supporting the generation and implementation of translational models 

• Establish and maintain effective collaborations with key peer and team stakeholders within QTAS, Discovery and Clinical to facilitate knowledge and data integration for target prioritization, biomarker selection, candidate selection, guidance in (pre)clinical study design, human dose prediction and calculation of therapeutic index 

• Effectively communicate on strategies related to drug metabolism and pharmacokinetics (DMPK) and translational modeling and simulation  

• Maintain awareness of emerging literature and science in computational approaches and applications