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Senior Scientist II, Biologics Purification

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North Chicago, North Chicago
Posted a month ago
67 views

Job Description

Join AbbVie’s Biologics Discovery Sciences group and make a tangible impact in advancing innovative biologic therapies. As a scientist specializing in Biologics Purification, you will play a pivotal role in driving drug discovery, collaborating within a dynamic team dedicated to supporting transformative science that improves patient lives worldwide. Your expertise will help deliver high-purity bispecific antibody-based biologic candidates with suitable purity/characteristics to support the advancement of vital in vitro (i.e. drug-like property assays, binding, cell-based assays, etc.) and in vivo studies (i.e. efficacy, non-GLP NHP PK, DRF, etc.). 

Key Responsibilities:

  • Lead the purification of bispecific antibody biologics to support critical research assays and studies
  • Champion the selection, integration and application of advanced in silico tools to optimize complex protein separation
  • Leverage Design of Experiments (DOE) with high throughput automation to evaluate and refine key process parameters to improve protein separation efficiency
  • Design and execute advanced chromatography techniques and robust bioprocess development strategies to address production liabilities and enable process scalability. 
  • Develop automated data capture workflows to enable AI/ML initiatives
  • Collaborate with multidisciplinary teams, translating molecular insights into functional results
  • Stay current with emerging scientific literature to foster innovation and continuous improvement
  • Present findings clearly to diverse audiences and document results with rigor
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