Purpose

Our In Vivo Pharmacology group in South San Francisco, CA has an opening for a motivated in vivo pharmacologist with experience in the development of biologic antigen-directed therapeutics (Antibodies, Antibody Drug Conjugates, etc.). This individual will support the in vivo strategy and coordination for various pipeline projects, and responsibilities will include tumor model selection, study design preparation, hands-on in vivo data collection, data analysis and presentation to project teams and stakeholders. The scientist will collaborate in a project team setting with biology, medicinal chemistry, biologics, and DMPK scientists to advance oncology agents through the preclinical R&D pipeline. The ideal candidate will be highly motivated, work independently, have excellent communication skills and previous industry experience in the oncology field.

Responsibilities

• Independently conceive and execute in vivo experiments utilizing human tumor models (CDX, PDX, orthotopic models) in immunocompromised mice.
• Strategize, design, execute and analyze in vivo data to assess the efficacy, PK and PD of novel therapeutics.
• Manage study operations within the team, including the coordination of study designs and timelines/resources.
• Critically evaluate scientific literature and external resources to identify innovative concepts, methods, or technologies and apply them effectively to solve problems and improve outcomes.
• Effectively collaborate across cross-functional teams, presenting research findings to project teams/governance bodies and preparing technical reports.
• Work with external contract research organizations to advance our understanding of oncology diseases.
• Understand and adhere to IACUC protocols regarding animal welfare and handling.
• Mentor and guide one or more scientists in the group, evaluating and ensuring their effective performance. People-management responsibilities will be dependent on previous experience.