Staff Software / Platform Engineer (South San Francisco, CA)

Position Overview

We are seeking an experienced Staff Engineer to help maintain, evolve, and scale our multi-repository e-commerce platform and internal tooling. This role is ideal for a highly versatile engineer who is comfortable working across multiple technology stacks and designing, building, and operating scalable systems in a modern microservices-based architecture.

As a Staff Engineer, you will serve as a technical leader developing and owning complex systems, influencing architectural decisions, and partnering closely with Product, Design, and DevOps to deliver reliable, high-quality solutions at scale. A strong systems-thinking mindset is essential to understand end-to-end workflows, cross-service interactions, and long-term system impacts.

Key Responsibilities

• Design, develop, and maintain frontend and backend systems across multiple repositories
• Apply systems thinking to reason about end-to-end architecture, dependencies, failure modes, scalability, and long-term maintainability
• Build responsive, performant user interfaces using React and TypeScript
• Design, implement, and maintain RESTful APIs using Java, Python, and Node.js
• Create and maintain API documentation using Swagger/OpenAPI
• Develop and operate containerized services using Docker and deploy on Kubernetes (EKS)
• Configure, maintain, and optimize CI/CD pipelines (Drone CI, Jenkins, Spinnaker)
• Monitor system health, performance, and reliability using logging, metrics, and observability tools
• Debug production issues and lead root cause analysis across distributed systems
• Integrate and support third-party systems, including payment platforms (e.g., Stripe)
• Collaborate cross-functionally with Product, Design, and DevOps to deliver end-to-end solutions
• Enforce best practices for Git workflows, code reviews, and release management
• Define and uphold microservices principles, including service boundaries, scalability, and system integrations

Preferred Skills & Experience

• 8+ years of professional software engineering experience with demonstrated impact on complex, distributed systems
• Strong full-stack experience across modern frontend and backend technologies
• Proficiency in systems thinking, including modeling system behavior, understanding trade-offs, and anticipating downstream effects of architectural decisions
• Deep understanding of distributed systems, microservices patterns, and API design
• Hands-on experience with AWS, including S3, EKS, WAF, Cost Explorer, and Bedrock
• Experience integrating with Salesforce (SFDC) or PROS APIs is preferred
• Strong communication skills with the ability to influence and collaborate across teams
• Proven ability to balance hands-on development with architectural ownership and technical leadership

About Twist Bioscience

Twist Bioscience synthesizes genes from scratch, known as “writing” DNA. Just as children learn to both read and write, the next phase of development for the genomics revolution is the ability to write DNA.

At Twist Bioscience, we work in service of people who are changing the world for the better. In fields such as health care, agriculture, industrial chemicals and data storage, our unique silicon-based DNA Synthesis Platform provides precision at a scale that is otherwise unavailable to our customers.

Twist Bioscience Corporation is an Equal Opportunity Employer. Twist Bioscience Corporation provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, genetic characteristics, or any other category protected by law.