About Hexagon Bio:

Hexagon Bio is a drug discovery company focused on developing next-generation antibody–drug conjugates (ADCs) with novel payloads derived from natural products. We combine genomics, data science, machine learning, synthetic biology, automation, and medicinal chemistry to discover evolutionarily refined small molecules from microbial genomes and advance them toward transformative cancer therapies.

Location: Menlo Park, CA

Job description:

Hexagon Bio is seeking a motivated and energetic Bioanalytical Scientist to join the Bioanalytical Chemistry team and play a key role in the in vitro and in vivo bioanalysis of antibodies and ADCs.

This role is ideal for a hands-on, laboratory-focused researcher who thrives in a fast-paced environment and is eager to support our preclinical research pipeline. This is a 100% on-site lab-based role.

Key Responsibilities

• Perform method optimization and implementation of LBA (Ligand binding Assay) based bioanalysis of large molecules including antibodies and ADCs.
• Execute quantitative assays in biological matrices for in vivo PK and TK studies to support the preclinical pipeline.
• Design and develop specific and sensitive LBA- ECL methods on Meso Scale Discovery instrument.
• Apply routine sample preparation using manual or automated liquid handling techniques (e.g., Hamilton Microstar).
• Maintain precise data records, analyze data sets, and interpret results.
• Collaborate closely with chemistry, protein science, and biology teams to ensure studies are designed and executed appropriately and data and conclusions are presented clearly
• Contribute to a team culture grounded in scientific rigor, transparency, and collaboration.

Qualifications

• Degree in Analytical Chemistry, Pharmaceutical Sciences, Biology, or a related field. Post-degree (B.S./M.S./PhD) industry experience in biotech or pharma is preferred. Fresh PhD graduates are welcome.
• Demonstrated quantitative bioanalytical laboratory experience. Proven hands-on experience in ELISA/ECL-MSD based large molecule quantitative bioanalysis.
• Knowledge and experience with LC (Liquid Chromatography) and/or mass spectrometry (MS) applications, especially Triple Quadrupole (QQQ) mass spectrometry is a plus. 
• Experience with ADCs and ADC payloads, or targeted oncology therapies is a strong plus.
• Strong communication skills and highly collaborative cross-functionally across teams.
• Flexibility to adapt to shifting priorities and a genuine passion for lab-based scientific work.

What We Offer:

• A dynamic, flexible environment with meaningful scientific ownership and impact.
• A transparent culture supported by regular All Hands meetings.
• Competitive compensation and a robust benefits package (medical, dental, vision, and voluntary benefits via TriNet).
• 401(k) plan 
• Access to Menlo Park Labs amenities, including shuttle service, gym, climbing wall, pool, sports courts, café, bike storage, and EV charging.
• Team-building events such as Hexagon Happy Hours and company celebrations.

Additional Information:

This is a temporary contract position for 9 months. The salary range is dependent on the level of Scientist that is hired.  The salary range for this contract position is $120,000 - $160,000. Our salary ranges are determined by role, level, and location. The range displayed on each job posting reflects the minimum and maximum target for new hire salaries for the position across California locations. Within the range, individual pay is determined by work location and additional factors, including job-related skills, experience, and relevant education or training.

Hexagon Bio is an equal opportunity employer and committed to a diverse workplace. All applicants will be considered equally without regard to race, color, ethnicity, veteran status, religion, national origin, marital status, political affiliation, age, sex, sexual orientation, disability status, membership in an organization, or any other non-merit factors.

Note to External Recruiters: Submission of unsolicited resumes prior to an agreement set in place does not create any implied obligation.