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The Position

Early Development Biometrics (EDB) is a core function within Product Development Data Sciences (PDD) that provides strategic leadership and scientific rigor across early clinical development at Roche. As strategic partners in drug development, we apply our drug development and statistical expertise to the design and analysis of clinical development plans, clinical studies, and non-clinical experiments.

We are seeking a motivated intern to join the Early Development Biometrics (EDB) team in Basel. You will develop a statistical framework to evaluate biomarkers as potential surrogate endpoints for use in early-phase clinical trials. In particular, you will explore the utility of causal mediation analysis in assessing the proportion of the treatment effect mediated by candidate surrogates. 

The Opportunity

• Evaluate various causal mediation methods to identify the most robust techniques for surrogate validation.

• Explore historical Roche trial data across diverse therapeutic areas: Ulcerative Colitis, Huntington’s Disease, and Alzheimer’s Disease etc.

• Conduct extensive simulation studies to stress-test causal mediation methods under different conditions.

• Develop reusable software/code to facilitate uptake of these methods for broader use within the biometrics team.

• Get familiar with existing methods through targeted literature review.

• Consolidate research findings and simulation results into clear presentations.

Who you are 

• You are enrolled in a Master or PhD program in Statistics or a related field, or you graduated from your Master's studies within 12 months before the internship start date. 

• Technical Skills: A strong theoretical foundation in statistics, experience in applied statistics and proficiency in the R programming language.

• Mindset: Highly organized, eager to learn, and passionate about connecting statistical theory with real-world drug development challenges.

• Bonus Points: Familiarity with causal inference (especially mediation analysis) is a plus.

• Language: Fluency in English.

Additional information

• You can learn more about Product Development Data Sciences (PDD) here: https://careers.roche.com/global/en/meet-our-data-scientists 

• The duration of the internship is between 3 to 6 months (ideally 6 months) .

• Your complete application includes the following documents: A current CV and a motivation Letter.

• Non EU/EFTA students must prove that they are enrolled at the University during the full duration of their internship and that the internship is a mandatory part of their curriculum.

We are looking forward to your application!

Who we are

A healthier future drives us to innovate. Together, more than 100’000 employees across the globe are dedicated to advance science, ensuring everyone has access to healthcare today and for generations to come. Our efforts result in more than 26 million people treated with our medicines and over 30 billion tests conducted using our Diagnostics products. We empower each other to explore new possibilities, foster creativity, and keep our ambitions high, so we can deliver life-changing healthcare solutions that make a global impact.

Let’s build a healthier future, together.

Roche is an Equal Opportunity Employer.