Senti Bio is seeking an enthusiastic, self-driven Research Associate to join its Process Development team that is focused on advancing new products and enabling technologies. This role will be part of a team of associates and scientists that develop processes and technologies for manufacturing NK-cell therapies. The position will require experimental execution, troubleshooting and optimization of processes, data analysis, drafting of and presentation of results.
Responsibilites
Contribute to process development for cell therapy development programs, including natural killer (NK cells) and other therapeutic cell modalities
Perform small- and large-scale experiments using primary cells to support multiple operations including expansion, gene editing, selection/expansion of clones, cell harvest and cryopreservation
Perform transductions on primary human cells via viral vectors and other gene delivery methods
Supports process optimization efforts to increase process robustness, improve transduction efficiency, cell yield and purity
Contribute to donor screening and testing processes using high-throughput assays.
Collaborate with research teams on relevant ex-vivo assays (Flow Cytometry, ELISA, Luminex based assays and PCR)
Maintain accurate lab records and notebooks
Author protocols, reports and standard operating procedure documents
Present results in team meetings and delivers presentation to both small and large groups
Qualifications
Bachelor’s or Master’s degree in Cell & Molecular Biology or related life science field, with a minimum of 2 years of experience, preferably in process development setting
Experience with mammalian tissue culture including both adherent and suspension cells.
Proficiency with flow cytometry strongly preferred.
Ability to design and execute experiments with minimal technical supervision. Ability to multitask and meet deadlines in a fast-paced environment.
Highly organized and detailed oriented individual with strong troubleshooting and problem-solving skills
Must be a team player, proactive and willing to work in a small team environment.
Must have excellent verbal and written communication skills.
Proficient with MS office and other commonly used software and technology platforms.
Self-motivated and eager to take on temporary responsibilities outside of initial job description.
