Who We Are

Arcellx is a public, clinical-stage biotechnology company reimagining cell therapy by engineering innovative immunotherapies for patients with cancer and other incurable diseases. We believe that cell therapies are one of the forward pillars of medicine and our mission is to destroy cancer and advance humanity by developing cell therapies that are safer, more effective, and more broadly accessible.

Our team members are made up of talented innovators and dreamers working from our offices in Rockville, Maryland, and Redwood City, California. At Arcellx, we hire exceptional people and create a fun, diverse, supportive, and informal environment that allows everyone to do their best work.

What Matters to Us

Living our core values is essential to maintaining a work environment that is high-performing, inclusive, and collaborative. We look for candidates who demonstrate strong values alignment and bring different backgrounds, viewpoints, and abilities to the team.

Arcellx Core Values

• Start with authenticity: We foster an inclusive environment where each person can bring their authentic self to work.
• Think ‘we’ before ‘me’: We prioritize collective success, collaborating and supporting one another to achieve our shared goals.
• Embrace the challenge: We deliver exceptional results by working with shared determination and a commitment to doing what’s right.

How You'll Make a Difference 

We are seeking a Senior Engineer I who is passionate about advancing cell therapy manufacturing. In this role, you will contribute to the development of phase-appropriate manufacturing processes for Arcellx’s cutting-edge cell therapy products. Our mission is to deliver high-quality therapies to clinical patients by leveraging both in-house and external manufacturing capabilities.

You will bring expert-level knowledge of CAR-T GMP manufacturing processes and a strong understanding of manufacturing batch records across multiple sites. This role combines technical expertise with hands-on laboratory skills in a Process Development/MSAT environment, driving initiatives in process design, characterization, optimization, and technology transfer to manufacturing sites. This is a high-visibility, impactful position within our Technical Operations organization—ideal for someone who thrives in a collaborative, fast-paced environment and is motivated by making a difference for patients. At Arcellx, we value passion, curiosity, determination, and diversity, and seek individuals who share our mission and values.

The “Fine Print” – What You’ll Do

Drive Laboratory Studies for Process Development and MSAT/Manufacturing

• Plan, organize, and execute lab experiments to support process development and manufacturing activities (e.g., investigations, process improvements, operator training).
• Provide technical expertise for T-cell manufacturing process changes, comparability assessments, deviations, investigations, change control, and regulatory submissions.
• Maintain accurate documentation, including lab notebooks, SOPs, and technical reports.
• Ensure a clean, safe, and compliant laboratory environment; manage equipment and supplies.
• Conduct studies on process understanding (e.g., lot-to-lot variability, hold times, software upgrades).
• Support technology transfer by testing and validating manufacturing batch records prior to implementation.
• Collaborate with internal and external partners (e.g., Analytical Development, Protein Sciences) for testing and related studies.
• Meet with MSAT/Manufacturing team regularly to conduct manufacturability assessments of any changes to the manufacturing process

Laboratory Management

• Manage purchase orders, vendor relationships, and material ordering for Lab operations
• Oversee weekly equipment checks, lab organization, and safety compliance as a Lab Safety Team representative.
• Contribute to development plans, process definition, and optimization strategies.
• Summarize and present data in team meetings; actively participate in technical discussions.
• Troubleshoot and resolve technical challenges independently and collaboratively.
• Travel to CA Arcellx Site up to 20% for training in manufacturing support as needed.

Skills and Experience We Look For

• BS in Chemical, Biological, Biomedical or Biochemical Engineering with 10+ yrs. of relevant experience, MS with 7+ yrs. of relevant experience, or PhD with 3+ years of relevant experience.
• Strong engineering, scientific and operational background in implementation of bioprocess unit operations and aseptic cell culture. 
• Strong understanding of process development, technical transfer, and GMP operations and documentation.
• Experience with T or B-cell cultures is a plus.
• MSAT/Manufacturing experience is a plus.

 Rewards at Arcellx

Our people are our greatest asset, and supporting their well-being is an essential part of delivering on our mission and impacting the lives of patients. Putting this belief into practice means offering strong compensation and benefits.

The estimated base salary range for this position is $145,000 - $165,000 per year. Where a candidate falls within that range is determined by factors such as years of experience. Our compensation package also includes an annual bonus based on company goals and an equity (RSU) grant. We do offer relocation assistance for roles if required.

Our market-leading benefits package includes: 100% coverage for medical, dental and vision for team members and dependents, unlimited vacation, a 3-day weekend every month, fully-paid parental leave for up to 6 months, tuition reimbursement, 401k employer contribution and more. 

Join us in our quest to reimagine cell therapy and destroy cancer. For more on our technology, culture, and team, go to www.arcellx.com.

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