We are seeking a Senior Scientist, High Throughput Screening to support our macrocycle discovery efforts. You will join a Series A-stage biotech startup co-founded by Nobel Prize-winning scientist David Baker, where the pace and flexibility of an early-stage company create significant opportunities for impact. You will work closely with a talented team, build a broad range of skills, and help shape Vilya’s culture, strategic direction, and research outcomes.

Vilya is a team-first organization, and we believe onsite work is essential to how we collaborate, move quickly, and build a strong culture. This is a fully onsite position in our South San Francisco office. Join us and help make a difference for patients!

RESPONSIBILITIES: 

• Independently design, develop, and execute biochemical, biophysical and cell based assays ensuring assay robustness and reproducibility 
• Minaturize and optimize assays for screening and SAR.
• Lead high-throughput screening (HTS) campaigns for various drug targets, including automated workflows, to drive preclinical drug discovery
• Collaborate frequently and effectively across biology, chemistry, automation, informatics, compute, and compound management teams to ensure seamless handoff of information and materials
• Analyze and QC experimental results, draw conclusions, and recommend future experiments
• Prepare written reports and presentations summarizing experimental outcomes and project status for peers and leadership
• Clearly communicate data, plans, and progress to the broader Vilya team
• Provide scientific expertise and make recommendations for new assays, screening technologies, instrumentation and improved screening workflows
• Proactively review scientific literature to incorporate new discoveries and technologies into Vilya’s research efforts
• Organize and maintain electronic work records 
• Participate in project teams as biology representative and subject matter expert 
• Demonstrate adaptability and flexibility in evolving environments and the ability to execute with urgency 

PREFERRED QUALIFICATIONS:

• Ph.D. or equivalent industry experience in Cell Biology, Molecular Biology, or Biochemistry
• Demonstrated leadership experience in an industry role (e.g., project team lead, people management, or program management)
• Experience with drug discovery laboratory techniques
• Hands on industry experience with automation and HTS using a variety of assay technologies
• Familiarity with automated liquid handling (e.g. Biomek i7, Formulatrix Tempest)
• Strong problem solving skills and ability to work collaboratively in a fast paced, team-first environment 
• Passion for scientific discovery and making a difference in the world

VILYA BENEFITS:

• Opportunity to work in a disruptive startup with a talented, experienced, and dedicated team
• 401(k) plan with employer matching for contributions
• Stock options
• Excellent medical, dental, and vision coverage
• Open, flexible vacation policy
• Support to attend professional conferences meaningful to your career growth
• Monthly cell phone and internet stipend
• Monthly wellness and commuter stipend

Salary Range: $125,000–$164,000/year