The Senior Scientist I will implement and execute novel scientific research and development, independently develop, optimize new methods and techniques to generate reliable and reproducible data in a timely manner and demonstrate broad versatile technical expertise. They will support early phase development of New Chemical Entities (NCEs), particularly synthetic peptides, in both the preclinical- and clinical-development space and collaborate within the global Analytical R&D organization and with R&D cross-functional partners such as Pre-Clinical Safety (PCS), Process Chemistry, Process Engineering, Drug Product Development (DPD), Quality Assurance (QA), and CMC-Regulatory Affairs.   

This position will focus primarily on transitioning NCEs from Discovery into Development Sciences and the individual will independently serve as an Analytical Research and Development representative in a highly cross-functional team, which includes Discovery, Process Chemistry, Quantitative and Translational ADME Sciences (QTAS), Safety Pharmacology, Pre-Clinical Safety (PCS), and Molecular Profiling and Drug Delivery (MPDD). Candidates should be comfortable discussing organic chemistry topics relevant to analytical chemistry, such as stereoisomers, common functional groups, and pKa values. Experience with peptide development is required and chromatographic analysis (such as HPLC or GC) and Mass Spectrometry is highly preferred. 

Responsibilities 

• Responsible for efficiently leading and supporting new peptide product development, from an analytical perspective, while working with cross-functional areas to advance projects through the development pipeline. 

• Support new peptide product development with advanced analytics to drive the pipeline and impactful research initiatives.  

• Utilize understanding of a range of analytical techniques to conduct research and development studies related to synthetic-molecule drug substances, impurities, and impurity profiling. 

• Highly autonomous and productive in performing laboratory research and/or method development, requiring only minimal direction from or interaction with supervisor. 

• Initiate new areas of investigation that are scientifically meaningful, reliable, and can be incorporated directly into a research or development program. 

• Formulate conclusions and design follow-on experiments based on multidisciplinary data. 

• Process, interpret, and visualize data to facilitate project team decisions. 

• Routinely demonstrate scientific initiative and creativity in research or development activities and maintain a high level of productivity in the lab. 

• Responsible for method development, testing procedures, and implementation of analytical control strategies to help the advancement of drug discovery candidates. 

• Raises the bar and is never satisfied with the status quo.