The Position

Evommune is hiring a Director, DMPK to provide scientific and strategic leadership across discovery and development programs. This role is critical to advancing our small-molecule pipeline from early discovery through clinical development.

The Director, DMPK will serve as the DMPK program lead, responsible for establishing and executing ADME, PK, and PK-PD strategies that inform candidate selection, IND-enabling activities, and first-in-human dose projections. As a subject-matter expert, this individual will partner closely with cross-functional teams to enable data-driven decision-making and efficient program execution.

This role reports to the Executive Director, Non-Clinical Development and offers the opportunity to play a visible, influential role in shaping Evommune’s growing pipeline.

Key Responsibilities

• Provide scientific and technical leadership for DMPK, PK, and PK-PD strategy across discovery and development programs
• Serve as DMPK program lead, with accountability for study design, execution, interpretation, and reporting
• Develop and implement DMPK strategies aligned with project and portfolio objectives, including candidate selection and first-in-human dose predictions.
• Partner closely with Medicinal Chemistry, Pharmacology, Toxicology, CMC, Bioanalytical, and Clinical teams to support integrated program advancement
• Oversee the design, analysis, and execution of in vivo and in vitro DMPK studies, ensuring timely communication of results to project teams and senior leadership
• Provide expert interpretation of DMPK data and present findings to internal stakeholders and external partners

• Author and/or oversee PK and DMPK sections of regulatory submissions (IND, IB, CTA, IMPD, NDA/BLA) and support regulatory interactions
• Manage and collaborate with CROs, consultants, and external partners to ensure high-quality execution and efficient use of resources
• Ensure scientific rigor, data integrity, and appropriate documentation across all DMPK activities
• Support the continued evolution and scaling of DMPK capabilities as the pipeline grows

Qualifications

• PhD in pharmacokinetics, drug metabolism, or a related discipline
• 10+ years of small-molecule DMPK experience within the pharmaceutical or biotechnology industry
• Proven track record of leading DMPK strategy for discovery and development programs
• Deep expertise in ADME, PK, and PK-PD with experience translating preclinical data to clinical development
• Experience with clinical candidate selection and first-in-human dose projections
• Hands-on experience analyzing PK and PK-PD data using relevant modeling and analysis tools
• Experience guiding the development and validation of bioanalytical methods for quantifying drug candidates and metabolites
• Strong understanding of regulatory guidelines supporting small-molecule development, including preparation and review of DMPK sections for regulatory submissions
• Experience supporting or leading interactions with U.S. and international regulatory agencies
• Demonstrated ability to influence program strategy and decision-making through DMPK insight

How You Will Lead

• Act as a trusted, influential partner to senior scientific and development leadership
• Drive the DMPK agenda with strategic thinking, scientific rigor, and a bias toward action
• Communicate complex data clearly and effectively to diverse audiences
• Operate effectively in a fast-paced, resource-constrained, startup environment
• Bring a collaborative, hands-on leadership style with strong problem-solving and analytical skills

Compensation

The salary range for this position is $190,000-$240,000, and the position may be eligible for performance-based bonuses and/or equity-linked compensation. Salary ranges are determined by role, level, and location, as well as additional factors such as job-related skills, experience, and relevant education or training. We offer Company-sponsored benefits, including comprehensive health, dental, and vision plans, as well as pet insurance. In addition, we offer a 401(k) plan, ample time-off programs, paid parental leave, life insurance, disability insurance, and an employee referral bonus program.

Evommune is proud to be an equal opportunity employer and will consider all qualified applicants for employment.