We are seeking a highly motivated Group leader Principal Research Scientist II reporting to head of Purification Development team to join the Purification Development group within Biologics Drug Substance Development organization.  Our group is responsible for the end-to-end development from first in human process development to late-stage process optimization, process scale up, tech transfer to clinical and commercial sites, and process characterization for all biologics modalities at AbbVie Bioresearch Center in Worcester, MA.  We contribute to the development of innovative and novel downstream technologies and create valuable intellectual property through the composition of matter and technologies resulting in cost-effective commercial manufacturing processes.

The core deliverable of downstream team is to develop robust manufacturing processes and advance innovative technologies using strong fundamentals.  The ideal candidate will have prior biologics purification experience and a passion for hands-on laboratory process development.  The candidate is also expected to lead the identification and development of novel approaches and technologies to enhance process development efficiency and commercialization. The candidate must exhibit a collaborative nature in identifying process challenges on a wide range of projects, take part in a cross-functional team to deliver specific project needs, and take on a leadership role in developing and implementing solutions.

Responsibilities:

• Effectively function as a Principal scientist reporting to head of Purification development team, generating original technical ideas and research or development strategies
• Lead development, optimization, scale-up, and tech transfer of purification processes for biologics candidates to support early and late-stage development
• Represent purification development team and actively influence development strategy on cross-functional CMC teams
• Transfer processes to pilot and GMP manufacturing
• Be hands-on and execute lab operations when needed in collaboration with direct reports and/or purification development team members to meet project deliverables
• Demonstrate creative 'out of the box' thinking to solve difficult problems and champion new technologies to achieve project goals.  Proactively seek out new tools, techniques, and strategies to implement into the overall downstream platform
• Advance scientific expertise and proactively demonstrates leadership by advises and sharing of expert opinions with subordinates, peers, and senior management.
• Generate new scientific proposals and lead those efforts. Anticipate and critically evaluate scientific or regulatory advances or competitive threats and respond with appropriate new strategies
• Write technical publications, reports, presentations, and regulatory filings, including publishing research in peer-reviewed journals and presenting work at scientific conferences
• Responsible for developing, communicating, and implementing the vision and strategy to fulfill functional goals and key scientific objectives. This also involves collaboration with experts within function to integrate scientific objectives into activities associated with development of new/improved products or technology.
• Work efficiently, collaboratively, and cross-functionally toward project timelines and goals
• Presents scientific concepts and results for functional scientific and non-scientific leaders as well as potential and existing partners. Maximizes impact and value of expertise.
• Mentor/supervise a team and evaluate the performance of those individuals; is accountable for the effective performance of the team/individuals