AbbVie is seeking an experienced scientist to join our Immunology team to develop, characterize, and qualify complex in vitro models (CIVMs). This lab-based individual will be responsible for duties that include but are not limited to: routine cell culture for cell lines and primary cells, creation and maintenance of complex in vitro models (e.g. organoid, organ-on-chip) for multiple different tissue types with a focus on modeling autoimmune diseases and performing quantitative endpoint assays. This is an ideal position for a candidate who wants to be at the forefront of 3D tissue modeling technologies and can thrive in a diverse research environment; strong organizational, multi-tasking, collaboration, and communication skills are critical.

Key Responsibilities

• Routine culture and maintenance of immortalized, stem, and primary cell cultures, both in standard formats as well as organoids or organ-on-chip formats. Experience with these systems, and with a variety of cell types (e.g. endothelial cells, intestinal organoids, fibroblasts, immune cells, etc.) is highly desirable.
• Isolation of primary human cells, including the isolation of primary cells from tissue and whole blood.
• Designing and conducting experiments to characterize in vitro models, including assessments of in vitro potency, cytotoxicity, transcript/protein abundance using techniques such as viability assays, microscopy, histopathology, and transcriptomics/proteomics. 
• Conducting experiments with a high level of independence and initiative and performing tasks with minimal direct supervision for routine methods.
• Independently schedule and prioritize workload to manage several tasks simultaneously and identify / utilize resources outside of your own group.
• Designing experiments to characterize models, generating foundational datasets to guide model selection for specific drug program needs.
• Maintaining detailed electronic documentation to ensure adherence to departmental procedures and contribute to final reports as needed.