AbbVie’s Immunology R&D organization is expanding its early discovery team at the Cambridge Research Center in Cambridge, MA. We are seeking a highly motivated Associate Scientist to join our Respiratory Discovery team and contribute to the identification and validation of novel therapeutics for inflammatory lung diseases. The Cambridge-based early discovery team integrates human disease transcriptomic and multi-omic data sets with mechanistic in vitro studies to elucidate disease-driving pathways and advance innovative therapeutic strategies. The successful candidate will play a key role in providing support for the implementation and optimization of complex human cell culture systems for the development of cellular assays.

The ideal candidate is scientifically curious, collaborative, enthusiastic, skilled, and dedicated. They should demonstrate a commitment to scientific rigor and teamwork within a fast-paced drug discovery environment.

Key Responsibilities

• Sterile cell culture (cell lines and primary cells)
• Establish, maintain and characterize primary human and immortalized culture systems relevant to respiratory disease biology, including epithelial cells, fibroblasts and immune cell populations
• Support the generation of complex in vitro cellular models
• Execute mechanistic cellular assays to investigate pathways involved in airway inflammation and tissue remodeling.
• Candidates with knowledge of the following techniques will receive extra consideration: flow cytometry, PCR/gene analysis, protein/cytokine measures via ELISA/MSD, western blotting and methods applicable to other lung-related endpoints.
• Analyze data and present work in internal meetings
• Maintain detailed experimental records and ensure compliance with electronic laboratory notebook

Key AbbVie Competencies

• Builds strong relationships with peers and cross functionally with partners outside of the team to enable high performance
• Learns fast, grasps the “essence” and can change course quickly where indicated
• Raises the bar and is never satisfied with the status quo
• Creates a learning environment, open to suggestions and experimentation for improvement
• Embraces the ideas of others and nurtures innovation to make possibilities real