This position requires a BSc / MSc level scientist to maximize the impact and productivity of the Chemical Biology and Mass Spectrometry and Technologies (CB&MST) team for generation of data to drive pipeline decisions. This scientist will work collaboratively with team members to transition routine, low throughput sample preparation procedures for target validation, target engagement, and off-target profiling into high precision / high throughput procedures with a focus in proteomics preparation methodologies and plate-based proteomics sample prep. The successful candidate will collaborate with teammates to optimize and perform automated sample preparation methodologies and conduct mass spectrometry-based proteomics experiments to enable this transformation.  

Key Responsibilities: 

Work with team members to develop, validate, and implement automated sample preparation workflows for CB&MST activities, with an emphasis on plate-based proteomics sample preparation using cell lines, tissues and other biological matrices. 

• Develop methods to automate chemical biology sample prep using magnetic bead-based enrichments and liquid handling. 

• Collaborate with team members to establish, document, and maintain Standard Operating Procedures for routine workflows.  

• Operate, monitor, and assist with the maintenance and troubleshooting of LC-MS instrumentation and associated laboratory equipment. 

• Assist with data processing, quality assessment, and data interpretation. 

• Interface and collaborate with colleagues and project teams in therapeutic areas to determine appropriate samples and amounts required for studies.