Manager, Site Reliability Engineer (Hybrid in South San Francisco)

About the Role

We are seeking an experienced and hands-on Site Reliability Engineering (SRE) Manager to lead our Site Operations and infrastructure initiatives. This role is responsible for ensuring the reliability, scalability, security, and performance of our cloud infrastructure and critical applications.

The ideal candidate combines strong technical expertise with leadership experience and a passion for operational excellence. You will lead efforts across cloud infrastructure, observability, automation, networking, and platform reliability while partnering closely with engineering and product teams to support business-critical applications.

Responsibilities

• Lead and manage the Site Operations / SRE function
• Own cloud infrastructure architecture, operations, scalability, and optimization
• Ensure high availability and reliability of production applications and services
• Drive operational excellence through automation, monitoring, and incident management
• Develop and maintain observability platforms including logging, metrics, alerting, and tracing
• Manage Kubernetes-based infrastructure and container orchestration environments
• Oversee networking, DNS, CDN, and storage infrastructure across cloud environments
• Collaborate with software engineering teams to improve deployment processes, system resilience, and performance
• Establish and improve CI/CD pipelines and infrastructure-as-code practices
• Lead incident response, root cause analysis, and post-incident remediation efforts
• Manage vendor and platform relationships where applicable
• Mentor and develop SRE / Site Operations engineers and foster a culture of reliability and continuous improvement
• Define and implement infrastructure security and compliance best practices

Required Qualifications

• 5–7+ years of experience in Site Operations, Site Reliability Engineering, Infrastructure Engineering, or related operational roles
• Prior experience leading or mentoring engineering or operations teams
• Strong hands-on experience with cloud infrastructure platforms (AWS, Azure, and/or GCP)
• Experience managing Kubernetes (K8s) environments in production
• Strong understanding of networking concepts including DNS, load balancing, firewalls, routing, and CDN technologies
• Experience with Akamai CDN administration and optimization
• Experience with observability and monitoring platforms, including Splunk
• Experience with storage infrastructure and cloud-native storage solutions
• Strong scripting and automation experience (Python, Bash, Terraform, or similar)
• Experience implementing and maintaining CI/CD pipelines
• Strong troubleshooting and incident management skills in complex distributed systems
• Excellent communication and cross-functional collaboration skills

Preferred Qualifications

• Experience managing hybrid or multi-cloud environments
• Experience with infrastructure-as-code and GitOps methodologies
• Familiarity with security best practices and compliance frameworks
• Experience supporting highly available enterprise or SaaS platforms
• Strong understanding of container security and cloud-native architectures

About Twist Bioscience

Twist Bioscience synthesizes genes from scratch, known as “writing” DNA. Just as children learn to both read and write, the next phase of development for the genomics revolution is the ability to write DNA.

At Twist Bioscience, we work in service of people who are changing the world for the better. In fields such as health care, agriculture, industrial chemicals and data storage, our unique silicon-based DNA Synthesis Platform provides precision at a scale that is otherwise unavailable to our customers.

Twist Bioscience Corporation is an Equal Opportunity Employer. Twist Bioscience Corporation provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, genetic characteristics, or any other category protected by law.