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Job Function:

Career Programs

Job Sub Function:

Post Doc – Drug Discovery & Pre-Clinical/Clinical Development

Job Category:

Career Program

All Job Posting Locations:

Spring House, Pennsylvania, United States of America

Job Description:

About Innovative Medicine

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow. Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.

Learn more at https://www.jnj.com/innovative-medicine

We are searching for the best talent for a Postdoctoral Scholar, Translational PK/PD in Spring House, PA.

Purpose: The Translational PK/PD & Investigative Toxicology (TPPIT) team, has strong expertise in characterizing ADCs and payloads from both experimental and modeling aspects, and the scholar will work as part of a dynamic, cross site team within a highly collaborative TPPIT environment, partnering with cross functional colleagues across ADC data generation, analysis, and translational PK/PD modeling.  This is a two-year position with the possibility of a third-year extension.

You will be responsible for:

• Advancing translational PK/PD strategies for antibody-drug conjugates (ADCs) by integrating in vitro, preclinical, and clinical datasets to define exposure-response relationships.
• Building predictive in vitro models using 2D/3D cell culture systems and cell-based assays to characterize ADC and payload activity.
• Using experimental data, PK/PD modeling, and quantitative analysis to inform ADC candidate selection, support human dose projection, and reduce reliance on animal studies.

Qualifications / Requirements:

Education: PhD with 0-1 years of experience. Preferred degrees in chemical or biomedical engineering or biopharmaceuticals.

Experience/Skills Required:

• Wet-lab experience in cell culture, including 2D and 3D culture systems, and cell-based assays such as cytotoxicity assays; familiarity with microscopy and imaging techniques.
• Proficiency in data analysis software such as Prism and ImageJ, and MATLAB or familiarity with at least one PK/PD modeling platform such as Monolix or Phoenix.

Preferred Skills:

• Experience with cell and molecular biology assays, including the Incucyte live-cell analysis system; familiarity with PK/PD modeling.
• ADC or drug conjugate experience.

Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act. 

Johnson & Johnson is committed to providing an interview process that is inclusive of our applicants’ needs. If you are an individual with a disability and would like to request an accommodation, external applicants please contact us via https://www.jnj.com/contact-us/careers , internal employees contact AskGS to be directed to your accommodation resource.

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