AbbVie’s Immunology R&D organization is looking for a highly motivated Scientist I to join our Dermatology Discovery team at the Cambridge Research Center in Cambridge, MA. This researcher will contribute to the identification and validation of novel therapeutics for inflammatory skin diseases. The Dermatology Discovery team applies human disease transcriptomic and multi-omics data sets in combination with wet-bench science to perform mechanistic in vitro studies with the overarching goal to elucidate disease-driving mechanisms that will advance innovative therapeutic strategies. The successful candidate will play a key role in the preclinical research team by conducting in vitro models focusing on human translation to HS and PsO.  

The ideal candidate is scientifically curious, collaborative, enthusiastic, skilled, and dedicated. This position requires passion, attention to detail, prior hands-on experience, and teamwork within a fast-paced drug discovery environment. 

Key Responsibilities: 

• Sterile cell culture (cell lines and primary human and murine cells) 

• Process and analyze ex-vivo human tissues for disease-relevant endpoints  

• Perform analyses using the following techniques: 

1.      Flow cytometry 

2.      Quantitative PCR 

3.      Protein analyses – ELISA, MSD and multiplex assays 

4.      Western blotting 

5.      Microscopy 

• Develop and implement assays that monitor cellular processes 

• Analyze data using appropriate statistical methods and communicate findings through presentations and scientific discussions 

• Maintain detailed experimental records and ensure compliance with electronic laboratory notebook

• Prior hands-on experience with keratinocytes, fibroblasts, and immune cells (Th17 T cell differentiation, macrophage polarization) is a plus

• Candidates with prior experience in complex human in vitro model will receive extra consideration