The Precision Medicine Immunology department is seeking a highly motivated and talented Scientist with a background in immunology or immuno-oncology and experience in single-cell or spatial genomics, molecular biology, and cell biology to join the Translational Research team. This individual will provide leadership in clinical biomarker discovery by profiling clinical samples using single-cell and spatial omics approaches to better understand drug mechanism of action and pharmacodynamics, while driving data-informed patient selection strategies. The role will support drug development programs across inflammatory and autoimmune disease areas, including Dermatology, Gastroenterology, Rheumatology, and Fibrosis, from late-stage discovery through clinical trials. The successful candidate will join a growing translational research group and collaborate with cross-functional teams both internally and externally. 

Key Responsibilities 

• Independently lead the design, execution, and analysis of complex genomic profiling experiments, including single-cell RNA-Seq, CITE-Seq, and spatial transcriptomics/proteomics. 

• Perform image analysis tasks for spatial transcriptomics and proteomics datasets, including de-array and alignment for multi-omics integration, cell segmentation and phenotyping. 

• Design, develop and implement computational pipelines for processing and analyzing spatial omics datasets, including spatial transcriptomics and proteomics. 

• Proactively identify technical artifacts, interpret quality control results, optimize assay performance, and ensure high quality and reproducible data delivery on timely deadlines. 

• Stay at the forefront of the single-cell and spatial genomics field by surveying, evaluating, testing and validating novel scientific methodologies. 

• Present work plans and acquired data clearly and precisely to cross-functional stakeholders through formal written reports and verbal updates