The role of an Senior Scientist, Oligonucleotide Chemist within the Innovation Hub team in Petaluma, CA, USA. Is to develop and / or improve synthesis, deprotection, purification, modification, and analysis methods and processes to enable the introduction of new oligonucleotide related products and the transfer of these into manufacturing.

• Ensure compliance with safety regulations and Quality Management policies and processes.
• Is the Technical Lead in Oligonucleotide NPD and / or custom / co-creation projects.
• Collaborate with multidisciplinary teams to support both IH and Operations project deliverables.
• Core function is to act as the technical oligonucleotide chemistry lead and contribute to the development and delivery of new oligonucleotide-based technologies and applications
• Demonstrated ability to independently design, project plan and execute development projects.
• Independently develop synthesis methods to enable the delivery of custom / co-creation / NPD oligonucleotides using automated synthesizers and manual techniques.
• Independently develop and optimize methods for oligonucleotide modification and conjugation (on-column and post synthesis and deprotection).
• Independently develop and optimize purification methods for various modified oligonucleotides and conjugates. 
• Perform analytical characterization of oligonucleotides using HPLC, mass spectrometry, and other relevant techniques. 
• Troubleshoot synthesis, deprotection and purification processes to resolve manufacturing issues and / or improve yield and quality.
• Independently generate documentation package to support operations effective control and transfer into manufacturing
• Act as the subject matter expert post tech transfer and assist with chemistry troubleshooting.
• Maintain accurate records of experiments and results in accordance with laboratory protocols
• Prepare technical reports and present findings to internal and external stakeholders.  Effective communication at all business and technical levels.