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Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us.

The Protein Homeostasis Thematic Research Center at BMS is a fundamental Oncology research engine delivering oncology and hematology therapeutics to patients. The TRC has a major focus on exploiting BMS’ expertise in protein degradation to discover and develop therapies aimed at tumor intrinsic vulnerabilities and mechanisms of resistance to existing cancer therapeutics. This focus on protein degradation allows us to attack protein classes that were previously deemed undruggable.

Job Summary

We are actively seeking a highly motivated and scientifically rigorous Senior Scientist with deep expertise in spatial transcriptomics, NGS-based assay development, and multi-omics technologies to join the Protein Homeostasis Department at Bristol Myers Squibb (BMS) in San Diego. The successful candidate will play a key role in developing, implementing, optimizing, and applying cutting-edge spatial and multi-omic workflows to support early drug discovery, target identification, target validation, mechanism-of-action studies, and translational biology across oncology programs.

This role will sit at the interface of spatial biology, molecular profiling, functional genomics, tissue biology, and computational analysis. The scientist will work closely with disease-area biologists, translational scientists, computational biologists, pathology, genomics, automation, and project teams to generate high-quality, decision-enabling datasets from patient-derived models, preclinical samples, perturbation studies, and compound-response experiments.

The ideal candidate will bring strong hands-on experience with spatial transcriptomics platforms such as Visium HD, Xenium, GeoMx, CosMx, or related technologies, along with a solid understanding of NGS library preparation, tissue/sample quality control, imaging-based workflows, and downstream data interpretation. The candidate should be comfortable operating in a fast-paced, matrixed discovery environment and translating complex spatial and multi-omics data into actionable biological insights that inform therapeutic hypotheses, experimental strategies, and drug-discovery decisions. The candidate will join a collaborative and cross-functional team focused on driving early target discovery across various indications and contributing to innovative drug-discovery efforts with the potential to directly impact patient health.

Position Responsibilities

• Lead the design, optimization, execution, and troubleshooting of spatial transcriptomics and multi-omics workflows to ensure high-quality data generation and support early discovery programs.

• Recognize risks in drug discovery projects and experimental plans to provide recommendations for effective contingency strategies while maintaining alignment with research project timelines.

• Develop and implement experimental strategies using platforms such as 10x Genomics Visium HD, Xenium, NanoString GeoMx/CosMx, or related spatial biology technologies, depending on project needs and sample context.

• Generate high-quality spatial transcriptomics datasets from FFPE, fresh-frozen, preclinical, patient-derived, organoid, xenograft, or other disease-relevant models.

• Partner with disease biology, translational pathology, computational biology, and project teams across the organization to align experimental design with biological hypotheses, downstream analysis needs, and decision-making criteria.

• Apply spatial and multi-omic approaches to characterize cellular heterogeneity, tissue architecture, cell-state transitions, pathway modulation, drug response, resistance mechanisms, and therapeutic mechanism of action.

• Establish robust QC criteria for tissue integrity, RNA quality, library quality, imaging performance, segmentation, sensitivity, specificity, reproducibility, and data usability.

• Work with bioinformatics and computational partners to support first-pass data review, data interpretation, visualization, and clear biological storytelling.

• Stay current with the latest advancements in sequencing, spatial biology, and multi-omics technologies to contribute to the evaluation and implementation of emerging spatial and multi-omics platforms and workflows to enhance discovery capabilities.

• Support automation, workflow standardization, documentation, sample tracking, and reproducible data-generation practices.

• Serve as a scientific resource for spatial transcriptomics and multi-omics experimental design across cross-functional partner teams.

• Communicate results clearly through technical reports, project team presentations, internal seminars, and scientific strategy discussions.

• Create official reports and SOPs for both internal and external purposes, and prepare internal documents/reports to support program documentation and regulatory filings.

• Mentor junior scientists or research associates to provide scientific guidance and contribute to a collaborative, innovative, and quality-focused team culture.

Basic Qualifications:

• Bachelor’s Degree

  • 7+ years of academic and / or industry experience

Or

• Master’s Degree

  • 5+ years of academic and / or industry experience

Or

• Ph.D. or equivalent advanced degree in the Life Sciences

  • 2+ of academic and / or industry experience

Preferred Qualifications:

• Ph.D. in Molecular Biology, Biochemistry, biotechnology, or biology with 2+ years of postdoctoral and/or industry experience in NGS, Spatial Transcriptomics, and multi-omics technologies.

• Proficiency in molecular biology and emerging NGS technologies, including spatial transcriptomics and single-cell or multi-omics profiling, with a track record of applying, optimizing, and validating NGS-based assays.

• Demonstrated expertise and creativity in designing, optimizing and deploying spatial transcriptomics, single-cell genomics, and multi-omics workflows.

• Demonstrated exceptional problem-solving abilities and attention to detail, with the ability to proactively identify technical risks and develop innovative solutions

• Excellent analytical abilities, with the ability to independently integrate and interpret complex biological datasets to advance research projects and present conclusions at project team meetings.

• Direct experience with one or more spatial platforms, such as 10x Genomics Visium HD, Xenium, NanoString GeoMx/CosMx, MERSCOPE, CellScape, or other imaging-based or sequencing-based spatial technologies.

• Strong understanding of tissue processing, RNA quality assessment, NGS library preparation, molecular biology, and spatial assay design.

• Experience with experimental design for complex biological studies, including appropriate controls, replication strategy, sample prioritization, and QC planning.

• Working knowledge of spatial data analysis concepts, including cell segmentation, cell typing, neighborhood analysis, spatial domains, pathway scoring, and visualization.

• Familiarity with R, Python, Seurat, Scanpy, Squidpy, Giotto, Loupe Browser, Xenium Explorer, Space Ranger, or similar tools.

• Effective team player with excellent written and verbal communication skills and the ability to foster successful collaboration within multidisciplinary teams.

• Ability to interpret transcriptomic and/or multi-omic datasets in collaboration with computational scientists.

• Ability to foster impactful collaborative genomics initiatives within the organization and across diverse research programs to drive drug discovery projects.

• Experience working with oncology, immuno-oncology, solid tumor, targeted protein degradation, molecular glue, or induced-proximity biology programs.

• Familiarity with patient-derived organoids, xenografts, co-culture systems, CRISPR perturbation screens, compound screens, or functional genomics workflows.

• Experience developing standardized workflows, technical reports, SOPs, automation-compatible protocols, or cross-functional sample/data tracking systems.

• Proven ability to organize multiple concurrent projects and tasks, work efficiently, and meet project timelines.

• Strong planning and organizational skills, with comfort using collaborative documentation and project-management systems such as Confluence, JIRA, or SharePoint.

#LI-Onsite

If you come across a role that intrigues you but doesn’t perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.

San Diego - CA - US: $131,590 - $159,454

The starting compensation range(s) for this role are listed above for a full-time employee (FTE) basis. Additional incentive cash and stock opportunities (based on eligibility) may be available. The starting pay rate takes into account characteristics of the job, such as required skills, where the job is performed, the employee’s work schedule, job-related knowledge, and experience. Final, individual compensation will be decided based on demonstrated experience. 

Eligibility for specific benefits listed on our careers site may vary based on the job and location. For more on benefits, please visit https://careers.bms.com/life-at-bms/.
 

Benefit offerings are subject to the terms and conditions of the applicable plans in effect at the time and may require enrollment. Our benefits include:

• Health Coverage: Medical, pharmacy, dental, and vision care.

• Wellbeing Support: Programs such as BMS Well-Being Account, BMS Living Life Better, and Employee Assistance Programs (EAP).

• Financial Well-being and Protection: 401(k) plan, short- and long-term disability, life insurance, accident insurance, supplemental health insurance, business travel protection, personal liability protection, identity theft benefit, legal support, and survivor support.

​Work-life benefits include:

Paid Time Off

• US Exempt Employees: flexible time off (unlimited, with manager approval, 11 paid national holidays (not applicable to employees in Phoenix, AZ, Puerto Rico or Rayzebio employees)

• Phoenix, AZ, Puerto Rico and Rayzebio Exempt, Non-Exempt, Hourly Employees: 160 hours annual paid vacation for new hires with manager approval, 11 national holidays, and 3 optional holidays

Based on eligibility*, additional time off for employees may include unlimited paid sick time, up to 2 paid volunteer days per year, summer hours flexibility, leaves of absence for medical, personal, parental, caregiver, bereavement, and military needs and an annual Global Shutdown between Christmas and New Years Day.

All global employees full and part-time who are actively employed at and paid directly by BMS at the end of the calendar year are eligible to take advantage of the Global Shutdown.

*Eligibility Disclosure: The summer hours program is for United States (U.S.) office-based employees due to the unique nature of their work. Summer hours are generally not available for field sales and manufacturing operations and may also be limited for the capability centers. Employees in remote-by-design or lab-based roles may be eligible for summer hours, depending on the nature of their work, and should discuss eligibility with their manager. Employees covered under a collective bargaining agreement should consult that document to determine if they are eligible. Contractors, leased workers and other service providers are not eligible to participate in the program.

Uniquely Interesting Work, Life-changing Careers
With a single vision as inspiring as “Transforming patients’ lives through science™ ”, every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in a supportive culture, promoting global participation in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

On-site Protocol

BMS has an occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role:

Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function.

Supporting People with Disabilities

BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to adastaffingsupport@bms.com. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.

Candidate Rights

BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.

If you live in or expect to work from Los Angeles County if hired for this position, please visit this page for important additional information: https://careers.bms.com/california-residents/

Data Protection

We will never request payments, financial information, or social security numbers during our application or recruitment process. Learn more about protecting yourself at https://careers.bms.com/fraud-protection.

Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.

If you believe that the job posting is missing information required by local law or incorrect in any way, please contact BMS at TAEnablement@bms.com. Please provide the Job Title and Requisition number so we can review. Communications related to your application should not be sent to this email and you will not receive a response. Inquiries related to the status of your application should be directed to Chat with Ripley.

R1602845 : Senior Scientist, Spatial Multi-Omics Biology for Early Drug Discovery