The Molecular Profiling and Drug Delivery (MPDD) function within the Small Molecule CMC organization is accountable for a broad range of deliverables across various stages of drug discovery and development. During lead optimization and through candidate selection, MPDD scientists utilize state of the art automation and computational tools supported by expertise in biopharmaceutics, drug delivery, and solid-state chemistry to collaboratively progress candidates with higher probability of success into development and advise clinical formulation strategy. From candidate selection through clinical proof of concept and product launch, MPDD scientists work in cross functional teams to identify the commercial solid form of the active pharmaceutical ingredient (API) and establish structure-property-performance correlations to help deliver robust commercial processes and align control strategies across drug substance and product. They also transition drug substance isolation processes and relevant physical characterization methods to commercial manufacturing sites and work within teams to ensure successful regulatory submissions. 

Drug Delivery scientists within AbbVie's MPDD organization work collaboratively with other functions within Development Sciences and Discovery to conduct developability assessment to select molecules with higher probability of success for clinical development and eventual commercialization.  This includes profiling of physicochemical properties, development of preclinical formulations, identifying solutions to in vivo absorption challenges, and advancement of novel drug delivery strategies across multiple routes of administration that are aligned with program target product profiles and downstream partners.  Modalities of interest include traditional small molecules as well as complex chemically synthesized modalities such as PROTACs and peptides.  In this role, you will work in cross-functional teams in matrixed environments and engage in multidisciplinary problem solving. 

Job Description 

AbbVie’s MPDD organization is seeking a highly motivated, creative, and collaborative scientist with expertise in chemical automation, assay development, and integrated workflow design for a Senior Scientist I position. The primary role of this position is to develop and implement automated and data-enabled workflows that accelerate decision-making and improve throughput in early development sciences. This individual will contribute to the profiling of physiochemical properties, screening and development of preclinical formulations, and the advancement of platform workflows for emerging modalities of interest. This role will work closely with cross-functional partners across discovery and development sciences to build and optimize integrated capabilities that support faster, data-driven, more efficient pipeline progression. The successful candidate will have strong hands-on experience in assay development, automation, and the generation and interpretation of physicochemical data to inform developability. Experience with preclinical formulation strategies, workflow optimization, and enabling technologies for novel or complex modalities is highly desirable. 

Level and compensation will be commensurate with experience.