Overview
The Development Sciences Biologics Drug Product Development organization within AbbVie develops and characterizes drug product formulations and manufacturing processes to provide clinical dosage forms to enable the development of AbbVie’s pipeline. AbbVie is seeking a highly motivated person to join the Biologics CMC Developability Team. Our team utilizes start-of-the-art biophysical and analytical instrumentation to assess candidates coming out of the Discovery pipeline. We collaboratively influence protein design paradigms to yield biologic candidates that will be successful drug products. Key to our success is developing models of protein structure and function to augment decision making in protein design and development. We utilize high throughput instrumentation and digital data systems to capture ML-ready data on industry leading datasets of therapeutic proteins. To drive maximum benefit from this data, we are seeking an experienced scientist to lead modeling efforts within our team. The successful candidate will bring deep experience of modeling protein stability or related properties to solve foundational questions such as viscosity, chemical degradation, and aggregation. Applicable modeling techniques could range from first principles to statistical based approaches. This role includes the opportunity to design molecules and custom studies for data generation, so knowledge of biochemistry experimentation is useful. The candidate will be a member of a global team and will work closely with scientists from multiple functional areas, including Discovery, Development Science Digital Transformation, and Information Research.

Key Responsibilities

• Serve as a technical expert for modeling within Biologics CMC Developability Team
• Represent BCD in modeling communities within AbbVie; collaborates with other modelers or teams to ensure business needs are met by the correct modeling framework
• May perform in vitro laboratory experiments; works closely with teams for design of wet lab studies to build both models and fundamental knowledge of protein solution behavior
• Identifies emerging scientific and technological trends from multiple internal and external sources, assesses relevance and integrates applicable trends into BCD plans and strategies as appropriate. Present data at internal and external professional conferences and prepare manuscripts for publication in peer reviewed journals or patent applications
• May serve as BCD Lead, coordinate developability assessment activities for 1-2 Discovery Projects at a time