The Development Sciences Biologics CMC Drug Substance Cell Line Development Group in South San Francisco, CA is seeking a Scientist I to join a talented, collaborative team developing CHO cell lines for GMP applications. In this laboratory-based role, the Scientist I will independently plan and execute molecular characterization studies that help advance novel therapies to clinical development. The work will encompass molecular, cellular, and bioprocess development studies relating to the generation and characterization of optimized CHO cell lines for production of our pipeline candidates.

Key Responsibilities

• Independently design, conduct, analyze, and document critical experiments supporting CHO cell-line development, cell-bank qualification, and candidate progression; assess data quality, troubleshoot results, and recommend next steps.
• Design and generate expression vectors for monoclonal antibodies and antibody-like molecules; improve cloning, plasmid QC, and whole-plasmid sequencing workflows.
• Characterize CHO cell banks for identity and transgene DNA/RNA quality using PCR/qPCR, ddPCR, DNA/RNA isolation, sequencing, and related assays.
• Develop and optimize NGS workflows, including RNA-seq and molecular screening; interpret sequencing data and establish fit-for-purpose quality controls.
• Author and review technical reports and documentation supporting regulated development from IND through BLA, following good documentation practices.
• Maintain protocols, tools, trackers, reference datasets, and inventories that improve reproducibility, traceability, and laboratory efficiency.
• Communicate scientific plans, results, and recommendations to cross-functional partners and external collaborators; document workflows and train colleagues as appropriate.
• Read, critically evaluate, and adapt scientific literature to guide experimental design and technical progress; independently implement appropriately scoped method and workflow improvements.