We seek a Senior Scientist II, Analytical Development to join an experienced, fast-paced and collaborative team. This position will be primarily responsible for guiding the biophysical analytical strategy and developing novel analytical methods for characterizing AbbVie’s mRNA-based targeted lipid nanoparticles (tLNPs) pipeline. This role will focus on developing novel biophysical methods for characterizing mRNA, lipids, and plasmids. Working collaboratively across discovery research, this position will develop novel characterization methods to support process/product understanding, expansion of the mRNA/tLNP platform and pipeline, and build structure-activity relationships.

 

Responsibilities & Duties:

• Develop novel biophysical methods to characterize mRNA drug substance, including but not limited to LC, CE, LC-MS, MALLS, mass photometry, and plate-based assays
• Improve plasmid characterization and build relationships to mRNA quality
• Support product characterization for tLNP platform/formulation development and lead candidate selection
• Lead mass-spec characterization of oligonucleotides, proteins, and lipids
• Support characterization of lipid content and related impurities
• Support implementation of automation/high throughput (HTP) workflows and in-process analytical methods for routine and non-routine testing
• Represent functional area in cross-functional pipeline and technology development teams
• Support method transfer and qualifications as needed
• Draft technical reports and documents as needed