AbbVie is seeking a highly motivated and experienced scientist to join our Quantitative, Translational & ADME Sciences (QTAS) team in North Chicago. The ideal candidate will have strong expertise in developing and implementing LC/MS-based bioanalysis and in vitro characterization assays for novel biologics. This role will support sample preparation, method development, bioanalytical assay operations, data analysis, report generation, and data presentation.

In this laboratory-based role, the scientist will help implement innovative quantitative and qualitative approaches to advance stability characterization of novel biologic entities using both conventional and more complex in vitro models. The position will also involve scientific leadership in the conduct of in vitro serum aggregation and stability assays for novel biologics. In addition, the successful candidate will qualify, validate, and evaluate new technologies while executing operational activities that support AbbVie’s growing novel biologics and genetic medicine pipeline.

Core Responsibilities:

• Operate and maintain LC/MS instruments to generate high-quality experimental data.
• Perform affinity purification of biotherapeutics, including but not limited to monoclonal and multispecific antibodies, antibody-drug conjugates, antibody-siRNA conjugates, and tLNPs.
• Analyze data and maintain detailed, accurate, and comprehensive study documentation in electronic laboratory notebooks. Communicate data interpretation internally and externally as needed.
• Support method development and assay optimization for quantitative bioanalysis and in vivo stability assessment of novel biologic entities to ensure laboratory capacity and data quality.
• Evaluate novel in vitro tools and methods, and apply established concepts to assess serum aggregation and stability of biologics and genetic medicine modalities.
• Serve as a characterization liaison for novel biologic entities within QTAS, partnering with QTAS representatives, HT-ABBA, Discovery BGM, ADC Discovery, and Conjugation teams to coordinate submissions, allocate requests, and review in vitro stability data.
• Stay current with emerging literature and scientific advances in biologics in vitro characterization and bioanalysis.
• Leverage AI-enabled tools and data-driven approaches to predict and deepen understanding of the biophysical and stability properties of biologics, supporting more efficient characterization and informed decision-making.
• Mentor/ supervise team of 2-3 scientist/senior scientist