Bring your scientific expertise to AbbVie and help drive the next wave of discovery in rheumatology. Join the Rheumatology team at the Cambridge Research Center as a Senior Scientist II within Discovery Immunology R&D. You will help shape preclinical drug discovery programs through target validation, mechanism-of-action studies, and translational research—connecting scientific insight with the development of potential new therapies.

Bring your expertise in immunology and inflammation biology, hands-on preclinical pharmacology experience, and in vivo model development skills to challenging questions in autoimmune disease. You will connect human disease biology with preclinical approaches and generate high-quality data packages that inform program decisions. Your scientific insight and experimental rigor will help advance differentiated therapeutic programs across the Immunology portfolio.

Key responsibilities include:

• Lead a team of scientists to generate high-quality data packages that support drug candidate advancement from lead optimization through IND filing.
• Drive in vitro and in vivo pharmacology for drug candidates, including establishing PK/PD relationships, developing and optimizing screening assays, designing and executing mechanism-of-action studies, and evaluating candidate efficacy.
• Develop acute and/or chronic murine models of inflammation relevant to rheumatological diseases, including RA, PsA, and SLE, to support preclinical candidate development.
• Apply immunological techniques such as flow cytometry, PCR/gene expression analysis, protein and cytokine quantification, histopathology, and other relevant functional readouts.
• Design experiments, analyze data, and present findings at AbbVie scientific forums and external conferences.
• Author and review technical reports, protocols, and other key scientific documents.
• Bring your pharmacology expertise to pipeline programs as a functional representative, contributing to target evaluation, mechanism-of-action (MoA) studies, and model development.
• Adhere to corporate standards related to code of conduct, documentation, safety, proper handling of materials, and humane treatment of laboratory animals.