The Quantitative, Translational ADME Sciences (QTAS) department at AbbVie is seeking a highly motivated scientist to join the Novel Biologic Entities-Bioanalysis and Translational Science group. The main function of this position is to develop and implement LC/MS (liquid chromatography/mass spectrometry)-based bioanalysis and characterization assays of novel biologics entities. The successful candidate will be experienced in the optimization and implementation of novel and routine LC/MS-based bioanalytical methods for protein and proteome characterization and quantitation to support in vivo PK, TK, and PK/PD studies as well as in vivo stability characterization of complex biotherapeutic modalities. The candidate will be responsible for sample preparation, method development, bioanalytical assay operations, data analysis, report generation, and data presentation. 

 
Key tasks and responsibilities:  

• Operate and maintain LC/MS instruments to generate high-quality experimental data. 
• Perform affinity purification of biotherapeutic (including but not limited to monoclonal and multispecific antibody, antibody drug conjugates, Fusion Proteins, antibody-siRNA conjugates, and tLNPs). 
• Perform proteomics/immunopeptidomics sample preparation workflows 
• Analyze data and maintain detailed, accurate and comprehensive study documentation in electronic laboratory notebooks. Communicate data interpretation internally and externally.
• Facilitate assay optimization and implementation to ensure laboratory capacity and data quality.
• Generate new scientific proposals and lead resulting efforts. Investigate, identify, develop, and optimize new methods and techniques. Act as a lead scientist in his/her area of expertise and critically evaluate relevant scientific and regulatory advances and integrate this knowledge into research or development programs.